Publications

Peer-reviewed publications (^contributed equally; undergraduate author at the time work was completed; reverse chronological order; updated September 2019)

 

  1. Rocío Arias del Razo, Trish Berger, Alan J. Conley, Sara M. Freeman, Leana R. Goetze, Suma Jacob, Rebecca H. Lawrence, Sally P. Mendoza, Emily S. Rothwell, Logan E. Savidge, Marjorie Solomon, Tamara A.R. Weinstein, Lynea R. Witczak, Karen L. Bales (accepted). Effects of Chronic Intranasal Oxytocin on Social Behavior, Anxiety, and Cerebral Glucose Uptake in Juvenile Titi Monkeys. Psychoneuroendocrinology.
  2. Amy Ryan, Sara M. Freeman^, Takeshi Murai^, Allison R. Lau, Michelle C. Palumbo, Casey E. Hogrefe, Karen L. Bales, and Melissa D. Bauman. Non-invasive eye tracking methods for New World and Old World primates. Frontiers in Behavioral Neuroscience. Mar 5;13:39. PMID: 30890923
  3. Sara M. Freeman, Michelle C. Palumbo, Rebecca H. Lawrence, Aaron L. Smith, Mark M. Goodman, and Karen L. Bales (2018). Effect of age and autism diagnosis on oxytocin receptors in the human basal forebrain and midbrain. Translational Psychiatry. Dec 4;8(1):257. PMID: 30514927
  4. Naomi R. Ondrasek, Sara M. Freeman, Karen L. Bales, and Rebecca M. Calisi (2018). Nonapeptide receptor distributions in promising avian models for the neuroecology of flocking. Frontiers in Neuroscience | Systems Biology. Oct 16;12:713. PMID: 30386202
  5. Sara M. Freeman and Karen L. Bales (2018). Oxytocin, Vasopressin, and Primate Behavior: Diversity and Insights. American Journal of Primatology. Oct;80(10):e22919. PMID: 30281814
  6. Sara M. Freeman, Julie Ngo, Bhavdeep Singh, Megan Masnaghetti, Karen L. Bales, and James E. Blevins (2018). Effects of chronic oxytocin and high fat diet on oxytocin and vasopressin 1a receptor expression in the rat brain. Neuroscience. Nov 10;392:241-25. PMID: 30071278
  7. Sara M. Freeman^, Nancy Rebout^, and Karen L. Bales (2018). Effect of reward type on object discrimination learning in socially monogamous coppery titi monkeys (Callicebus cupreus). American Journal of Primatology. Jun;80(6):e22868. PMID: 29756654
  8. Sarah Hartman, Sara M. Freeman, Karen L. Bales, and Jay Bielsky (2018). Prenatal Stress as a Risk and Opportunity Factor. Psychological Science. Apr;29(4):572-580. PMID: 29412055
  9. Auriane Duchemin, Adele M. H. Seelke, Trenton C. Simmons, Sara M. Freeman, and Karen L. Bales (2017). Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex. Neuroscience. Apr 21;348:201-211. PMID: 28214580
  10. Aaron L. Smith, Hasse Walum, Fawn Connor-Stroud, Sara M. Freeman, Kiyoshi Inoue, Lisa A. Parr, Mark M. Goodman, Larry J. Young (2016). An evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates. Bioorganic and Medicinal Chemistry. Jan 1; 25(1): 305–315. PMID: 27838170.
  11. Aaron L. Smith, Sara M. Freeman, Todd Barnhart, Elizabeth O. Ahlers, Dave Kukis, Dave Abbott, Karen Bales, Mark M. Goodman, and Larry J. Young (2016). Initial investigations of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys. Bioorganic and Medicinal Chemistry Letters. Jul 15;26(14):3370-5. PMID: 27209233
  12. Sara M. Freeman and Larry J. Young (2016). Comparative perspectives on oxytocin and vasopressin receptor research in rodents and primates: Translational implications. Journal of Neuroendocrinology. Apr;28(4). PMID: 26940141
  13. Amanda R. Chappell, Sara M. Freeman, Yu-teh K. Lin, Larry J. Young, and Loren D. Hayes (2016). Distributions of oxytocin and vasopressin 1a receptors in the Taiwan vole (Microtus kikuchii) and their role in social monogamy. Journal of Zoology. Jun;299(2):106-115. PMID: 27453637
  14. Sara M. Freeman, Aaron L. Smith, Mark M. Goodman, and Karen L. Bales (2016). Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem. Social Neuroscience. Mar 10:1-11. PMID: 26911439
  15. Sara M. Freeman, Sridhar Samineni, Philip C. Allen, Diane Stockinger, Karen L. Bales, Granger G.C. Hwa, Jeffrey A. Roberts (2016). Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques. Psychoneuroendocrinology. Apr;66:185-94. PMID: 26826355
  16. Emily S. Rothwell^, Sarah B. Carp^, Alexis Bourdon, Sara M. Freeman, Emilio Ferrer, and Karen L. Bales (2015). Development of a partner preference test that differentiates between established pair bonds and other relationships in socially monogamous titi monkeys (Callicebus cupreus). American Journal of Primatology. Mar;78(3):326-39. PMID: 26235811
  17. Benjamin J. Ragen, Sara M. Freeman, Sarah A. Laredo, Sally P. Mendoza, and Karen L. Bales (2015). µ and κ opioid receptor distribution in the monogamous titi monkey (Callicebus cupreus): Implications for social behavior and endocrine functioning. Neuroscience. Apr 2; 290: 421-34. PMID 25637809
  18. Sara M. Freeman, Hasse Walum, Kiyoshi Inoue, Aaron L. Smith, Mark M. Goodman, Karen L. Bales, and Larry J. Young (2014). Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus). Neuroscience. Jul 25; 273: 12–23. PMID: 24814726
  19. Sara M. Freeman, Kiyoshi Inoue, Aaron L. Smith, Mark M. Goodman, Larry J. Young (2014). The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta). Psychoneuroendocrinology. 45: 128-141. PMID: 24845184
  20. Kristina Gupta and Sara Freeman (2013). Preimplantation Genetic Diagnosis for Intersex Conditions: Beyond Parental Decision Making. The American Journal of Bioethics, 13(10): 1–3. PMID: 24024810
  21. Aaron L. Smith, Sara M. Freeman, Ronald J. Voll, Larry J. Young, Mark M. Goodman. Investigation of an F-18 Oxytocin Receptor Selective Ligand via PET Imaging (2013). Bioorganic and Medicinal Chemstry Letters. 23(19): 5415–5420. PMID: 23978650
  22. Aaron L. Smith, Sara M. Freeman, Ronald J. Voll, Larry J. Young, Mark M. Goodman (2013). Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging investigations for neural oxytocin receptors. Bioorganic and Medicinal Chemistry. Feb 1;23(3):902-6. PMID: 23270988
  23. Kelly Sink, David Walker, Sara Freeman, Elizabeth Flandreau, Kerry Ressler, and Michael Davis (2013). Effects of continuously
    enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety. Molecular Psychiatry. Mar;18(3):308-19. PMID: 22290119Textbook cover
  24. Sara M. Freeman and Larry J. Young. Oxytocin, Vasopressin, and The Evolution of Monogamy in Mammals.  In: Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior. Elena Choleris, Donald Pfaff, and Martin Kavaliers Eds. Cambridge Press. (c) 2013.
  25. Aaron Smith, Sara Freeman, Jeffrey Stehouwer, Kiyoshi Inoue, Larry Young, Mark Goodman (2012). Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors. Bioorganic and MedicinalChemistry. Apr 15;20(8):2721-38.
  26. Journal of Neuroscience Vole Brain CoverHeather E. Ross, Sara M. Freeman, Lauren L. Spiegel, Xianghui Ren, Ernest F. Terwilliger, and Larry J. Young (2009). Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles. Journal of Neuroscience. Feb 4;29(5):1312-1318. PMID: 19193878

Manuscripts in preparation (i.e. data collection and analysis are complete; undergraduate author at the time work was completed)

  • Sara M. Freeman. Using receptor autoradiography to visualize and quantify oxytocin and vasopressin 1a receptors in the human and nonhuman primate brain. In: Oxytocin: Methods and Protocols. Eds: Michael Kassiou, Erin Werry, and Tristan Reekie. Springer. Book series: Methods in Molecular Biology. Coming in 2020.
  • Sara M. Freeman, Michelle C. Palumbo, Rebecca H. Lawrence, Aaron L. Smith, Mark M. Goodman, and Karen L. Bales (in prep). Characterization of the distribution of oxytocin and vasopressin 1a receptors throughout the neurotypical human brain.
  • ­­Sara M. Freeman, Michelle C. Palumbo, Trenton C. Simmons, Aaron L. Smith, Mark M. Goodman, and Karen L. Bales (in prep). Effect of sex and autism on oxytocin and vasopressin 1a receptor densities in the hippocampus, substantia nigra, and primary visual cortex of the human brain.
  • Sara M. Freeman, Louise Loyant, Michelle C. Palumbo, Takeshi Murai, Melissa D. Bauman, and Karen L. Bales. (in prep). Non-invasive eye tracking reveals partner-directed looking behavior in monogamous titi monkeys (Callicebus cupreus).
  • Trenton C. Simmons, Sara M. Freeman, Nicholas S. Lackey, Brooke K. Dreyer, Devanand S. Manoli, and Karen L. Bales. Cannabinoid Receptor Type 1 Densities Reflect Social Organization in Microtus (in prep).
  • Kendall R. Davidek, Tiffany Chan, Sara M. Freeman, Marjorie Solomon, Suma Jacob, Sally P. Mendoza, and Karen L. Bales (in prep). The role of immediate post-treatment social context on effects of intranasal oxytocin in prairie voles (Microtus ochrogaster).
  • Rebecca H. Lawrence, Michelle C. Palumbo, Sara M. Freeman, and Karen L. Bales (in prep). Social and neural alterations from developmental SSRI exposure: Autism implications.